Author Archives: Jubie Wigan

JDRF Awards Ceremony

Charlie and I were not only honoured, but also extremely humbled, to have been given an award for our fundraising efforts at this year’s JDRF ‘Thank You’ ceremony in London a few weeks ago.  It was so amazing to see so many people there from all over the sough of England, all of whom had done their bit to not only raise money for JDRF, but more importably, helping to raise awareness for type 1.  Whether someone raised £50 through a cake sale, or £100,000, every pound is just as important, and brings us all that bit closer to finding the cure. I was so inspired by the energy and drive of everyone who was awarded, but particularly by the children themselves affected by the illness who went out of their way to raise money….I am full f respect and admiration for you all!

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We were ‘Type Onesies’ on World Diabetes Day

Apologies for my silence over the past few months, but with christmas, and birthdays, it has just been non-stop, but I will now try to do regular updates – 2015 is a big year for Sugarplum!!

We were so proud to have raised over £6000 for JDRF for World Diabetes Day, dressed as Unicorns!!  Thank you so much to all who donated, but in particular, to Aliena’s school – Great Tew Primary, and the village pub – The Falkland Arms in Great Tew – we were so touched and overwhelmed by your support.

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Atticus Aldridge Comes To Downton Abbey, A Character Born at The Sugarplum Dinner

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I was so excited to watch the arrival of ATTICUS ALDRIDGE to Downton Abbey last night  – a character born at The Sugarplum Dinner last year, after I approached the hugely talented Julian Fellowes to ask if he might consider auctioning the chance to have a character in your name on the show…..he said yes, and Atticus is the result!  My extremely generous friends bid a great deal of money to make this happen, choosing the name of their son, and what a perfectly Donwtonian name it is.  Played by the very handsome Matt Barber, we hope he will be on our screens for a while.

All money raised at the dinner – the auction alone raised £156k – went to JDRF, the world’s largest research charity for Type 1 diabetes, and other projects by Sugarplum Children, so we are all hugely grateful to everyone who donated money during the dinner.

Downton has always been one of my favourite shows on television, but is now extra special, knowing that I helped make telly history and have been part of something very special.  Now i have to hope we can offer the same auction prize next year…….watch this space!!

Long live Atticus!!!

Be a TypeOnesie on World Diabetes Day, 14th November

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World Diabetes Day is marked each year on 14th November by huge numbers of people around the globe.  For World Diabetes Day 2014, Sugarplum Children is working alongside JDRF to make their #TypeOnesie campaign even bigger than before, so we are encouraging as many schools as possible all over the UK to take part, by donating money to wear a onesie to school.

Last year’s World Diabetes Day was a triumph for all of us who are affected by type 1 diabetes, raising £53,000 to support diabetes research.  This year, we hope not only to raise eyebrows, smiles, and even more money, but most importantly, to raise awareness of life with the condition.

Whether you can donate £1, £5, £10, or £100 it will all go towards helping to find the cure for this horrible illness, and change the lives of all whom it affects, but in particular, the 29,000 children living in Britain: our brave little stars.

And for that, we will be eternally grateful.

For more information please email Jubie Wigan: jubie@sugarplumchildren.com

Payment/Social Media  Please collect all money raised, and then make one payment to the Sugarplum Children #TypeOnesie Just Giving page: www.justgiving.com/fundraising/sugarplum-children

And if you are able to promote awareness via soclai media, please use the following hashtags: #typeonesie #sugarplumchildren #bravelittlestars #type1diabetes

 

The News We have All Been Waiting For….

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Diabetes: a cure at last

Hannah Devlin

Friday 10th October 2014The Times

© Times Newspapers Limited 2014

Scientist devoted 23 years to research after infant son developed condition Diabetes treatment is a ‘game-changer’

A cure for diabetes is within reach after scientists developed a treatment that eliminates the need for sufferers to inject insulin.

The therapy involves a one-off transplant of laboratory-grown pancreatic cells, which scientists have finally succeeded in producing in large enough volumes to be able to treat patients. The cells worked normally for many months when implanted into mice, and the first human patients should undergo the treatment in the next few years.

The breakthrough by Harvard scientists was hailed yesterday as a medical advance potentially as significant as the advent of antibiotics. Jose Oberholtzer, an expert in transplantation at the University of Illinois at Chicago, predicted the development would “leave a dent in the history of diabetes“.

About 400,000 people in Britain have type 1 diabetes, including 30,000 children. The breakthrough could also help 10 per cent of Britain’s three million type 2 diabetes sufferers.

The advance is the culmination of 23 years of research by the Harvard scientist Doug Melton, who began working on type 1 diabetes when his son, Sam, had the condition diagnosed in childhood.

Professor Melton said yesterday that his team was now just one step away from the finish line, adding: “It was gratifying to know that we could do something that we always thought was possible, but many people felt it wouldn’t work.

“If we had shown this was not possible, then I would have had to give up on this whole approach. Now I’m really energised.”

Chris Mason, professor of regenerative medicine at University College London, said that if confirmed in a clinical trial the impact on diabetes would be “a medical game-changer on a par with antibiotics and bacterial infections”. The scientists are now in the last stages of animal testing in nonhuman primates.

Type 1 diabetes, which normally begins in childhood, is an autoimmune disease in which the body kills off all its pancreatic beta cells. The cells produce insulin, which regulates blood sugar. Without beta cells, the body’s sugar levels fluctuate wildly, meaning that patients need to monitor glucose and typically inject insulin several times each day.

In a study, published today in the journal Cell, Professor Melton’s team used embryonic stem cells and adult cells that had been genetically “rewound”.

Both these cell types have the ability to turn into any cell type in the body, but require the right biochemical environment to be “coaxed” down a particular developmental route. Scientists have struggled for years to get the set-up right to produce the volumes of pancreatic cells that would be necessary for clinical use.

Professor Melton’s team appears to have cracked this problem by identifying an efficient way to turn both stem cell types into beta cells.

When the cells were tested in the laboratory, they produced insulin, responded to glucose and appeared to work normally for many months when implanted in mice.

Crucially, a single production line of cells could be used to treat all patients, rather than each person needing their own genetically matched treatment, the study suggests.

Before being transplanted into the mice, the cells were placed in a porous capsule, which allowed insulin to diffuse out, but protected the cells from attacks by the body’s immune system.

This eliminated the need for geneticmatching to patients, meaning that cells could be produced on an industrial scale and used in patients without the risk of immune rejection. A further advantage would be that the capsule of cells could be quickly removed and replaced if it stopped working.

Although insulin injections help to keep glucose levels broadly in check, they do not match the body’s fine tuning, and this lack of control can eventually lead to complications from blindness to the loss of limbs.

Richard Elliott, of Diabetes UK, said that the treatment could “transform” the lives of people with the condition, although it was likely to be years before the cell-based therapy could be used routinely. “It could mean they no longer need to use insulin, which would be a historic breakthrough,” he added.

The treatment could also help the one in ten sufferers of type 2 diabetes who rely on insulin injections. Type 2 diabetes, which is diet related, occurs when the insulin cells stop working properly or when the body stops responding normally to insulin.

The discovery of a new type of “good” fat made in the body could help to prevent and treat type 2 diabetes. The previously unidentified lipid molecules increase insulin sensitivity and blood sugar control.

Unlike omega-3 fatty acids found in oily fish, the good fat named fatty acid hydroxyl fatty acids, or FAHFAs, are molecules found in fat cells as well as other cells throughout the body.

The NHS estimates that in England there are 3.1 million people over 16 with diabetes but by 2030 the figure is expected to rise to 4.6 million, with nine out of ten sufferers having type 2 diabetes.

The new findings, made by a team of scientists from Beth Israel Deaconess Medical Center in Boston and the Salk Institute in California, were published online by the journal Cell.

Profile Professor Melton

The satisfaction for Doug Melton, right, is as much personal as it is professional. His son was found to have type 1 diabetes when he was six months old. Later, his daughter received the same diagnosis. The Harvard professor, who completed his PhD in molecular biology at Trinity College, Cambridge, told The New York Times: “Like any parent, I asked myself, ‘What can I do?’ The answer was to shift my research to an area that might help them. I wanted my children to know I was doing everything I could.”

He had to overcome scepticism and political hurdles. In 2001 he secured private funding when George W Bush cut research into new stem cell lines. In 2007 he appeared on Time magazine’s list of the 100 most influential people.

 

‘Giant leap’ to type 1 diabetes cure

By James GallagherHealth editor, BBC News website

Insulin injectionScientists were able to transform stem cells into insulin-producing beta cells

The hunt for a cure for type 1 diabetes has recently taken a “tremendous step forward”, scientists have said.

The disease is caused by the immune system destroying the cells that control blood sugar levels.

A team at Harvard University used stem cells to produce hundreds of millions of the cells in the laboratory.

Tests on mice showed the cells could treat the disease, which experts described as “potentially a major medical breakthrough”.

Beta cells in the pancreas pump out insulin to bring down blood sugar levels.

But the body’s own immune system can turn against the beta cells, destroying them and leaving people with a potentially fatal disease because they cannot regulate their blood sugar levels.

It is different to the far more common type 2 diabetes which is largely due to poor lifestyle.

Perfect cocktailThe team at Harvard was led by Prof Doug Melton who began the search for a cure when his son was diagnosed 23 years ago. He then had a daughter who also developed type 1.

He is attempting to replace the approximately 150 million missing beta cells, using stem cell technology.

Beta cellsLab-made beta cells were transplanted into the mice

He found the perfect cocktail of chemicals to transform embryonic stem cells into functioning beta cells.

Tests on mice with type 1 diabetes, published in the journal Cell, showed that the lab-made cells could produce insulin and control blood sugar levels for several months.

Dr Melton said: “It was gratifying to know that we could do something that we always thought was possible.

“We are now just one pre-clinical step away from the finish line.”

However, his children were not quite so impressed: “I think, like all kids, they always assumed that if I said I’d do this, I’d do it.”

If the beta cells were injected into a person they would still face an immune assault and ultimately would be destroyed.

More research is needed before this could become a cure.

‘Game-changer’Sarah Johnson, from the charity JDRF which funded the study, told the BBC: “This isn’t a cure, it is a great move along the path. It is a tremendous step forward.

“Replacing the cells that produce insulin as well as turning off the immune response that causes type 1 diabetes is the long-term goal.”

Prof Chris Mason, a stem cell scientist at University College London, said: “A scientific breakthrough is to make functional cells that cure a diabetic mouse, but a major medical breakthrough is to be able to manufacture at large enough scale the functional cells to treat all diabetics.

“This research is therefore a scientific and potentially a major medical breakthrough.

“If this scalable technology is proven to work in both the clinic and in the manufacturing facility, the impact on the treatment of diabetes will be a medical game-changer on a par with antibiotics and bacterial infections.”

Dr Gillian Morrison, from the University of Edinburgh, agreed that this “represents a real advance in the field”.

She said: “The next important challenge will be to find ways to maintain these cells inside the body so they are protected from the immune response and have long-term function.”

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My New Role as Consultant…And Patient!

Aliena’s school very kindly asked me to come in and talk a bit about diabetes, as this week they’re learning about doctors and nurses, something which I was thrilled to do, knowing that the more her friends understand her condition, the more supportive they will be.

It was hugely rewarding hearing them all asking questions with genuine interest (well, for 5 year olds anyway!), and I felt very proud of myself, being able to pass on all that I have learned about the good soldiers and the bad soldiers inside Aliena’s body.  What I hadn’t been warned about was that after my session as ‘consultant’, I was then to become the patient for half an hour…..from which I still haven’t recovered!!!!!  As you can see from the pictures, they were an enthusiastic bunch  – let’s just say I feel a little too old for playing doctors and nurses…!IMG_2010

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Tears & Tugging At The Heart Strings – Starting Big School

My darling Aliena just started at her big school last week – off she went, so grown up in her uniform, book bag and diabetes kit in hand, new shoes as shiny as a mirror – not one look back, not one tear from her, whereas I was a mess.   I never expected to feel so overwhelmed, but having to start all over again with new teachers knocked me for six.

Due to the teachers not being trained yet to do the blood tests or administer the insulin via pump, I’ve had to go over to the school (which is on my doorstep thank goodness) every 2 hours, which has just wrenched my heart every time. Having to pull her away from her friends to stick yet more needles in those little paint and mud stained fingers just goes against every bone in a parent’s body.  But she has never complained, so why do I find it so hard?? or is that the point, the less she complains, and the more accepting she is, the more painful it is for us?

This week has been easier, and I’m sure they teachers will get the hang of it in no time at all, but I just wanted to share this as Im sure there are 100s of you in the same boat, so please feel free to share, to moan, to cry, or to admit there is a certain element of relief at finally being able to handover control to someone else for a few hours each day…..we are all in this together, so must carry each other along every step of the way, so onwards and upward we go.

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