I was so excited to watch the arrival of ATTICUS ALDRIDGE to Downton Abbey last night – a character born at The Sugarplum Dinner last year, after I approached the hugely talented Julian Fellowes to ask if he might consider auctioning the chance to have a character in your name on the show…..he said yes, and Atticus is the result! My extremely generous friends bid a great deal of money to make this happen, choosing the name of their son, and what a perfectly Donwtonian name it is. Played by the very handsome Matt Barber, we hope he will be on our screens for a while.
All money raised at the dinner – the auction alone raised £156k – went to JDRF, the world’s largest research charity for Type 1 diabetes, and other projects by Sugarplum Children, so we are all hugely grateful to everyone who donated money during the dinner.
Downton has always been one of my favourite shows on television, but is now extra special, knowing that I helped make telly history and have been part of something very special. Now i have to hope we can offer the same auction prize next year…….watch this space!!
Long live Atticus!!!
Diabetes: a cure at last
Friday 10th October 2014The Times
© Times Newspapers Limited 2014
Scientist devoted 23 years to research after infant son developed condition Diabetes treatment is a ‘game-changer’
A cure for diabetes is within reach after scientists developed a treatment that eliminates the need for sufferers to inject insulin.
The therapy involves a one-off transplant of laboratory-grown pancreatic cells, which scientists have finally succeeded in producing in large enough volumes to be able to treat patients. The cells worked normally for many months when implanted into mice, and the first human patients should undergo the treatment in the next few years.
The breakthrough by Harvard scientists was hailed yesterday as a medical advance potentially as significant as the advent of antibiotics. Jose Oberholtzer, an expert in transplantation at the University of Illinois at Chicago, predicted the development would “leave a dent in the history of diabetes“.
About 400,000 people in Britain have type 1 diabetes, including 30,000 children. The breakthrough could also help 10 per cent of Britain’s three million type 2 diabetes sufferers.
The advance is the culmination of 23 years of research by the Harvard scientist Doug Melton, who began working on type 1 diabetes when his son, Sam, had the condition diagnosed in childhood.
Professor Melton said yesterday that his team was now just one step away from the finish line, adding: “It was gratifying to know that we could do something that we always thought was possible, but many people felt it wouldn’t work.
“If we had shown this was not possible, then I would have had to give up on this whole approach. Now I’m really energised.”
Chris Mason, professor of regenerative medicine at University College London, said that if confirmed in a clinical trial the impact on diabetes would be “a medical game-changer on a par with antibiotics and bacterial infections”. The scientists are now in the last stages of animal testing in nonhuman primates.
Type 1 diabetes, which normally begins in childhood, is an autoimmune disease in which the body kills off all its pancreatic beta cells. The cells produce insulin, which regulates blood sugar. Without beta cells, the body’s sugar levels fluctuate wildly, meaning that patients need to monitor glucose and typically inject insulin several times each day.
In a study, published today in the journal Cell, Professor Melton’s team used embryonic stem cells and adult cells that had been genetically “rewound”.
Both these cell types have the ability to turn into any cell type in the body, but require the right biochemical environment to be “coaxed” down a particular developmental route. Scientists have struggled for years to get the set-up right to produce the volumes of pancreatic cells that would be necessary for clinical use.
Professor Melton’s team appears to have cracked this problem by identifying an efficient way to turn both stem cell types into beta cells.
When the cells were tested in the laboratory, they produced insulin, responded to glucose and appeared to work normally for many months when implanted in mice.
Crucially, a single production line of cells could be used to treat all patients, rather than each person needing their own genetically matched treatment, the study suggests.
Before being transplanted into the mice, the cells were placed in a porous capsule, which allowed insulin to diffuse out, but protected the cells from attacks by the body’s immune system.
This eliminated the need for geneticmatching to patients, meaning that cells could be produced on an industrial scale and used in patients without the risk of immune rejection. A further advantage would be that the capsule of cells could be quickly removed and replaced if it stopped working.
Although insulin injections help to keep glucose levels broadly in check, they do not match the body’s fine tuning, and this lack of control can eventually lead to complications from blindness to the loss of limbs.
Richard Elliott, of Diabetes UK, said that the treatment could “transform” the lives of people with the condition, although it was likely to be years before the cell-based therapy could be used routinely. “It could mean they no longer need to use insulin, which would be a historic breakthrough,” he added.
The treatment could also help the one in ten sufferers of type 2 diabetes who rely on insulin injections. Type 2 diabetes, which is diet related, occurs when the insulin cells stop working properly or when the body stops responding normally to insulin.
The discovery of a new type of “good” fat made in the body could help to prevent and treat type 2 diabetes. The previously unidentified lipid molecules increase insulin sensitivity and blood sugar control.
Unlike omega-3 fatty acids found in oily fish, the good fat named fatty acid hydroxyl fatty acids, or FAHFAs, are molecules found in fat cells as well as other cells throughout the body.
The NHS estimates that in England there are 3.1 million people over 16 with diabetes but by 2030 the figure is expected to rise to 4.6 million, with nine out of ten sufferers having type 2 diabetes.
The new findings, made by a team of scientists from Beth Israel Deaconess Medical Center in Boston and the Salk Institute in California, were published online by the journal Cell.
Profile Professor Melton
The satisfaction for Doug Melton, right, is as much personal as it is professional. His son was found to have type 1 diabetes when he was six months old. Later, his daughter received the same diagnosis. The Harvard professor, who completed his PhD in molecular biology at Trinity College, Cambridge, told The New York Times: “Like any parent, I asked myself, ‘What can I do?’ The answer was to shift my research to an area that might help them. I wanted my children to know I was doing everything I could.”
He had to overcome scepticism and political hurdles. In 2001 he secured private funding when George W Bush cut research into new stem cell lines. In 2007 he appeared on Time magazine’s list of the 100 most influential people.
‘Giant leap’ to type 1 diabetes cure
By James GallagherHealth editor, BBC News website
The hunt for a cure for type 1 diabetes has recently taken a “tremendous step forward”, scientists have said.
The disease is caused by the immune system destroying the cells that control blood sugar levels.
A team at Harvard University used stem cells to produce hundreds of millions of the cells in the laboratory.
Tests on mice showed the cells could treat the disease, which experts described as “potentially a major medical breakthrough”.
Beta cells in the pancreas pump out insulin to bring down blood sugar levels.
But the body’s own immune system can turn against the beta cells, destroying them and leaving people with a potentially fatal disease because they cannot regulate their blood sugar levels.
It is different to the far more common type 2 diabetes which is largely due to poor lifestyle.
Perfect cocktailThe team at Harvard was led by Prof Doug Melton who began the search for a cure when his son was diagnosed 23 years ago. He then had a daughter who also developed type 1.
He is attempting to replace the approximately 150 million missing beta cells, using stem cell technology.
He found the perfect cocktail of chemicals to transform embryonic stem cells into functioning beta cells.
Tests on mice with type 1 diabetes, published in the journal Cell, showed that the lab-made cells could produce insulin and control blood sugar levels for several months.
Dr Melton said: “It was gratifying to know that we could do something that we always thought was possible.
“We are now just one pre-clinical step away from the finish line.”
However, his children were not quite so impressed: “I think, like all kids, they always assumed that if I said I’d do this, I’d do it.”
If the beta cells were injected into a person they would still face an immune assault and ultimately would be destroyed.
More research is needed before this could become a cure.
‘Game-changer’Sarah Johnson, from the charity JDRF which funded the study, told the BBC: “This isn’t a cure, it is a great move along the path. It is a tremendous step forward.
“Replacing the cells that produce insulin as well as turning off the immune response that causes type 1 diabetes is the long-term goal.”
Prof Chris Mason, a stem cell scientist at University College London, said: “A scientific breakthrough is to make functional cells that cure a diabetic mouse, but a major medical breakthrough is to be able to manufacture at large enough scale the functional cells to treat all diabetics.
“This research is therefore a scientific and potentially a major medical breakthrough.
“If this scalable technology is proven to work in both the clinic and in the manufacturing facility, the impact on the treatment of diabetes will be a medical game-changer on a par with antibiotics and bacterial infections.”
Dr Gillian Morrison, from the University of Edinburgh, agreed that this “represents a real advance in the field”.
She said: “The next important challenge will be to find ways to maintain these cells inside the body so they are protected from the immune response and have long-term function.”
Aliena’s school very kindly asked me to come in and talk a bit about diabetes, as this week they’re learning about doctors and nurses, something which I was thrilled to do, knowing that the more her friends understand her condition, the more supportive they will be.
It was hugely rewarding hearing them all asking questions with genuine interest (well, for 5 year olds anyway!), and I felt very proud of myself, being able to pass on all that I have learned about the good soldiers and the bad soldiers inside Aliena’s body. What I hadn’t been warned about was that after my session as ‘consultant’, I was then to become the patient for half an hour…..from which I still haven’t recovered!!!!! As you can see from the pictures, they were an enthusiastic bunch – let’s just say I feel a little too old for playing doctors and nurses…!
My darling Aliena just started at her big school last week – off she went, so grown up in her uniform, book bag and diabetes kit in hand, new shoes as shiny as a mirror – not one look back, not one tear from her, whereas I was a mess. I never expected to feel so overwhelmed, but having to start all over again with new teachers knocked me for six.
Due to the teachers not being trained yet to do the blood tests or administer the insulin via pump, I’ve had to go over to the school (which is on my doorstep thank goodness) every 2 hours, which has just wrenched my heart every time. Having to pull her away from her friends to stick yet more needles in those little paint and mud stained fingers just goes against every bone in a parent’s body. But she has never complained, so why do I find it so hard?? or is that the point, the less she complains, and the more accepting she is, the more painful it is for us?
This week has been easier, and I’m sure they teachers will get the hang of it in no time at all, but I just wanted to share this as Im sure there are 100s of you in the same boat, so please feel free to share, to moan, to cry, or to admit there is a certain element of relief at finally being able to handover control to someone else for a few hours each day…..we are all in this together, so must carry each other along every step of the way, so onwards and upward we go.
I just wanted to share with you an email I received a few weeks ago form a fellow T1 mother. No explanation needed…..all i can say is it really is such a small world, and makes us realise how many other parents are out there dealing with the same daily T1 routine as we are, which can never be a bad thing.
I just wanted to share that today I sat outside at a service station near Minehead about to feed my son who has type1 and has had for just over 3 years. I looked up to see an all too familiar routine going on at the next table – finger pricks, hurriedly trying to work out the carb count before the accu check meter turns off etc.
it struck me how quickly i recognised the body language and how we go through this process as though its second nature now.
Anyway I vaguely recognised from the article in the YOU MAGAZINE and then stumbled upon your website – such a fab idea. Our local support group may be closing down and we have found their support invaluable since Saul’s diagnosis – don’t get me wrong my friends are fantastic but no one understands like another type 1 mum.
After looking at all of the fantastic work that you have been doing I just wanted to say thank you. Being proactive helps me to feel as though I am helping my son fight this horrible condition!
Lucy Westley and family
Apologies for my silence over the past month or so – i have been wanting to update the site on at least a weekly, if not daily, basis, but there just seems to be so much going on at the moment, most importantly, Aliena going onto to an insulin pump. I was so hoping to do a weekly update of how we were finding it, and i know its not too late, so will do a summary by the end of this week i hope. But for now, i will say it’s been AMAZING – life changing. Yes, ups and downs, but so so much easier than injecting her every time she eats.
And guess what makes it all so much easier – it’s PINK!!!!
Lots of other Sugarplum news to come……having to buy pump cases has inspired me to produce our won range of Sugarplum Children pen cases, insulin pouches and so on, so i will be in touch with everyone to get ideas and feedback, once I get the ball rolling. Initial meeting with production company is in 2 weeks, so watch this space.
We have only just gone live to coincide with the amazing article in YOU magazine, so the content isn’t complete yet, so more information will be added bit by bit. We would love to hear any feedback you may have, and if you would like to be involved, and have experience of living with a child with type 1, then please do get in touch. Find out more…